ReBoot (CGI), on YTV (Canada) / ABC & syndication (USA)
BCDB; Cartoon Network Wiki; IMDb; Retro Junk; Shout! Factory; TV Tropes; Wikia; Wikipedia
streaming sites: Amazon; Google Play; iTunes; ShoutFactoryTV; Vudu; YouTube
For more links see cartoon links.
I'm not sure how much of this Saturday morning cartoon I saw, nor do I even remember what channel I saw it on (because I certainly didn't get ABC at the time). But I do hope to get it on DVD someday, at which point I'll probably write a proper review.
For now, I can say that this was apparently the first-ever entirely CGI cartoon, which is impressive, I guess. Anyway, I always thought that it was kind of like the movie Tron (but not really). It's set inside the internet, or something, in like a sort of virtual world called Mainframe. There were these guardian sprites who protected Mainframe from like viruses, I guess. The main guardian was named Bob, and he was friends with this woman named Dot Matrix, who had a little brother named Enzo. The main villains were Megabyte and Hexadecimal. And that's all I can tell you.