Joey, on NBC
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This was a spin-off of Friends. Joey Tribbiani moved from New York to L.A. to pursue his acting career. (He eventually got a role on a TV show called "Deep Powder.") His move put him back in contact with his sister Gina; her son Michael (a rocket scientist) moves out of her house and in with his uncle Joey. There's also a neighbor named Alex, with whom Joey becomes friends, while her husband is often travelling (besides being the landlord, he's in an orchestra). Plus we occasionally see Joey's agent, Bobbie. Eventually, Alex and her husband separate. And Joey starts dating a new neighbor, a photographer named Sara, and their relationship gets pretty serious... until the first season finale. I can't think of much else to say about the show, but it definitely had its moments. It didn't last long, and it wasn't great, but it was probably better than most people gave it credit for. Though now that it's been off the air for several years, I don't remember it all that well. I mean, I remember the characters well enough, but not much in the way of plot. But it was reasonably funny.