Caroline in the City, on NBC (Must See TV)
IMDb; Sitcoms Online; TV Tango; TV Tropes; Wikipedia
streaming sites: Paramount+

Lea Thompson played a cartoonist named Caroline Duffy. Amy Pietz (who I'd later like better in Aliens in America) played her best friend, Annie. Malcolm Gets played Richard Karinsky, a frustrated painter who was working as the colorist for Caroline's comic strip. He was quite sarcastic, and I always thought he was the best part of the show. He and Annie hated each other. There were a couple other guys named Del and Charlie who I barely remember, just because they're mentioned on Wikipedia. I don't know why my memory of this show is so lacking, but I suppose I never was a big fan of it, and probably didn't watch the whole series.