The Amazing Live Sea Monkeys, on CBS
IMDb; TV.com; Wikipedia

This only ran for 11 episodes, on Saturday mornings. It was pretty surreal and redonkulous, but I don't remember it very well, and I'm not sure how much I liked it. But the vague fact of its existence is definitely quite memorable, and now I'd like to see it again. I'd probably like it more now than I did when I was a kid. Anyway, Howie Mandel played a wacky scientist called the Professor (he had like a funny accent and like fake white facial hair or something). He had enlarged these three sea monkeys (the kind sold in the back of old comic books, in a bygone era) to human size. Their names were Aquarius, Bill, and Dave. They were all really weird. And they had a friend named Sheila (played by Eliza Schneider, whom I'd later see on Beakman's World). But the main thing I remember about the show is the Professor always saying "silly sea monkeys!" when they'd say or do weird things. Or whatever.